Bone Induction: Regeneration through Chaos

The answer is perhaps more apparent than what is generally believed. An experiment conducted by Ripamonti et al. (1997), provided a new concept, which moved away from studying the effects of single stimuli and how these effected bone formation. Loading a biomimetic matrix with more than one morphogen, osteogenic protein-1 (OP-1) and TGF-β 1 , and then implanting these into heterotopic (non-bony) sites of P. ursinus showed a near twofold increase in the amount of bone formed as compared to any previous bone regeneration experiments (Ripamonti et al., 2010). Though it could be argued that the yield of bone formation by induction through the usage of these two morphogens is still lower than that of a bone graft, the findings may have inadvertently provided a possible solution for improving the stimulation of bone induction into macroporous devices, when the molecular analytical results are taken into account. Even though the synergy is more successful in inducing bone formation than either the scaffold solo or with each morphogen implanted singly, the molecular data revealed that OP-1 and TGF-β 3 expression is directly dependant on each other (Ripamonti, 2004). Experiments in Bone induction: regeneration through chaos